Ralhan I, Do AD, Bae J, Feringa FM, Cai W, Chang J, Chik K, Lee NYJ, Gerry C, Kant RVD, Jackson J, Ricq EL & Ioannou MS (2025). Protective ApoE variants support neuronal function by effluxing oxidized phospholipids . Neuron. 10.1016/j.neuron.2025.10.040
Rubio-Atonal LF, Chang J, Jacquemyn J, Ralhan I, Ilarraza I & Ioannou MS (2025) Glutamate decreases oxidative stress and lipid droplet formation in astrocytes. J Cell Sci. 10.1242/jcs.263983
Andersen JV, Aldana BI, Bak LK, Behar KL, Borges K, Carruthers A, Cumming P, Derouiche A, Díaz-García CM, Drew KL, Duarte JMN, Ferreira GC, Giove F, Gjedde A, Hyder F, Ioannou MS, Kann O, Kristian T, Lai JCK, Mason GF, McNay EC, Nedergaard M, Nowak TS Jr, Patel AB, Rae CD, Ryan TA, Schuck PF, Simpson IA, Vannucci SJ, Waagepetersen HS, Yellen G, McKenna MC. (2025) Embracing Scientific Debate in Brain Metabolism. J Neurochem. 169(9):e70230
Bae JY, Jacquemyn J & Ioannou MS (2024) Neuronal AMPK regulates lipid transport to microglia. Trends Cell Biol. 34(9):695-697
Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS & Bellen HJ (2024) Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nat Neurosci. 10.1038/s41593-024-01740-1
Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D (2024) A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 10.1038/s41556-024-01360-8
Jacquemyn J, Ralhan I & Ioannou MS (2024) Driving Factors of Neuronal Ferroptosis. Trends Cell Biol. S0962-8924(24)00022-9
Kumar R, Francis V, Ioannou MS, Aguila A, Khan M, Banks E, Kulasekaran G & McPherson PS (2023) DENND2B activates Rab35 at the intercellular bridge, regulating cytokinetic abscission and tetraploidy. Cell Rep 42(7):112795.
Ralhan I, Chang J, Moulton MJ, Goodman LD, Lee NJY, Plummer G, Pasolli HA, Matthies D, Bellen HJ & Ioannou MS (2023) Autolysosomal exocytosis of lipids protect neurons from ferroptosis. J Cell Biol. 222 (6): e202207130 preprint on bioRxiv https://doi.org/10.1101/2022.11.24.517842
Rubio-Atonal LF & Ioannou MS (2023) Astrocytic OxPhos: more than just energy production. Nature Metab. 5, 362-363.
Ralhan I, Chang CL, Lippincott-Schwartz J & Ioannou MS (2021) Lipid droplets in the nervous system. J Cell Biol. 220 (7): e202102136.
Moulton MJ, Barish S, Ralhan I, Chang J, Goodman LD, Harland JG, Marcogliese PC, Johansson JO, Ioannou MS & Bellen HJ (2021) Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer’s Disease-associated Genes. Proc Natl Acad Sci USA 118(52):e2112095118. Preprint on BioRxiv: 10.1101/2021.03.03.433580
Ioannou MS (2020) Current Insights into Fatty Acid Transport in the Brain. J Membr Biol 253: 375–379.
Matthies D, Lee NYJ, Gatera I, Pasolli HA, Zhao X, Liu H, Walpita D, Liu Z, Yu Z & Ioannou MS (2020) Microdomains form on the luminal face of neuronal extracellular vesicle membranes. Sci Rep 10(1): 11953.
Ioannou MS, Liu Z & Lippincott-Schwartz J (2019) A Neuron‐Glia Co‐culture System for Studying Intercellular Lipid Transport. Curr Prot Cell Biol 84(1):e95
Chang CL, Weigel A, Ioannou MS, Pasolli HA, Xu SC, Peale D, Shtengel G, Freeman M, Hess H, Blackstone C & Lippincott-Schwartz J (2019) Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III. J Cell Biol 218(8): 2583 preprint on bioRxiv https://doi.org/10.1101/544023
Ioannou MS, Jackson J, Sheu SH, Chang CL, Weigel AV, Liu H, Pasolli HA, Xu CS, Pang S, Matthies D, Hess HF, Lippincott-Schwartz J & Liu Z (2019) Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity. Cell 177(6):1522-1535. preprint on bioRxiv https://doi.org/10.1101/465237
Condon ND, Heddleston JM, Chew TL, Lou L, McPherson PS, Ioannou MS, Hodgson L, Stow JL & Wall AA (2018) Macropinosome Formation by Tent-Pole Ruffling on Macrophages. J Cell Biol 217(11):3873-3885 https://doi.org/10.1083/jcb.201804137
Taylor A, Ioannou MS, Aaron J & Chew TL (2018) Model-Free quantification and visualization of colocalization in fluorescence images. Cytometry A 93(5):504-516
Liu H, Dong P, Ioannou MS, Li L, Shea J, Pasolli A, Grimm J, Rivlin J, Lavis LD, Koyama M & Liu Z (2018) Stochastic labeling microscopy enables long-term visualization of single particles in vivo. Proc Natl Acad Sci USA 115(2): 343-348 preprint on bioRxiv https://doi.org/10.1101/116186
Ioannou MS, Kulasekaran G, Fotouhi M, Morein JJ, Han C, Tse S, Nossova N, Han T, Mannard E & McPherson PS (2017) Intersectin-s interaction with DENND2B facilitates the recycling fate of EGFR. EMBO rep 18, 2119-2130
Taylor A, Ioannou MS, Watanabe T, Hahn K & Chew TL (2017) Perceptually accurate display of two greyscale images as a single colour image. J Microsc 268(1): 73-83
Ioannou MS & Fahnestock M (2017) ProNGF, but not NGF, switches from neurotrophic to apoptotic activity in response to reductions in TrkA receptor levels. Int J Mol Sci 18 (3) pii. E599
Ioannou MS, Girard M & McPherson PS (2016) Rab13 traffics on vesicles independent of prenylation. J Biol Chem 291(20): 10726-10735.
Ioannou MS & McPherson PS (2016) Rab-mediated membrane trafficking and the control of epithelial cell polarity. J Cell Biol 213(3): 301-303 https://doi.org/10.1083/jcb.201604076
Ioannou MS & McPherson PS (2016) Regulation of cancer cell behavior by the small GTPase Rab13. J Biol Chem 291(19): 9929-2239
Kulasekaran G, Nossova N, Marat AL, Lund I, Cremer C, Ioannou MS & McPherson PS (2015) Phosphorylation dependent regulation of connecdenn/DENND1A guanine-nucleotide exchange factor. J Biol Chem 290(29), 17999-8008
Ioannou MS, Bell ES, Girard M, Chaineau M, Hamlin JNR, Daubaras M, Monast A, Park M, Hodgson L & McPherson PS (2015). DENND2B activates Rab13 at the leading edge of migrating cells driving cancer cell metastasis. J Cell Biol 208(5), 629-48 https://doi.org/10.1083/jcb.201407068
Hamlin JN, Schroeder LK, Fotouhi M, Dokainish H, Ioannou MS, Girard M, Summerfeldt N, Melançon P & McPherson PS. (2014) Scyl1 scaffolds class II Arfs to selective subcomplexes of coatomer via with γ–COP appendage domain. J Cell Sci 127(7), 1454-1463
*Chaineau C, *Ioannou MS & McPherson PS (2013) Rab35: GEFs, GAPs and effectors. Traffic 14(11), 1109-1117 *Equal contribution
Ioannou MS & Marat AL (2012) The Role of EHD at the neuronal synapse. Sci Signal 5(221):jc1
Marat AL, Ioannou MS & McPherson PS (2012) Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton. Mol Biol Cell 23(1), 163-175
Masoudi R, Ioannou MS, Coughlin MD, Pagadala P, Neet KE, Clewes O, Allen SJ, Dawbarn D & Fahnestock M (2009) Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. J Biol Chem 284 (27), 18424-18433
Ioannou Lab 